Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

Abstract Parasites infect hosts in widely varying environments, encountering diverse challenges for adaptation. To identify malaria parasite genes under locally divergent selection across a large endemic region with a wide spectrum of transmission intensity, genome sequences were obtained from 284 c...

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Bibliographic Details
Main Authors: Craig W. Duffy, Alfred Amambua-Ngwa, Ambroise D. Ahouidi, Mahamadou Diakite, Gordon A. Awandare, Hampate Ba, Sarah J. Tarr, Lee Murray, Lindsay B. Stewart, Umberto D’Alessandro, Thomas D. Otto, Dominic P. Kwiatkowski, David J. Conway
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Gametocytes
Falciparum
Gambiae
Long-read Sequencing Data
Recent Directional Selection
Online Access:https://doi.org/10.1038/s41598-018-34078-3

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