Ideal tissue regeneration option following periapical surgery

• Main Authors: Malti Tuli, Alankrutha Gangasani, Muqthadir Siddiqui Mohammed Abdul, Manpreet Kaur, Sunil Kumar Gulia, Piyush Raj Dharmi
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Journal of Dental Research and Review
• Subjects: allogenous bone grafts; apicoectomy; guided tissue regeneration
• Online Access: http://www.jdrr.org/article.asp?issn=2348-2915;year=2020;volume=7;issue=4;spage=232;epage=235;aulast=Tuli
• ISSN: 2348-2915; 2348-3172

Optimal tissue regeneration in the periapical region is essential following a periapical surgery. Literature shows that augmenting the osseous defect with artificial bone substitutes, growth factors, or barrier membranes acts as critical factors influencing the healing following surgical intervention. For the regeneration of tissues following periapical surgery, an essential requisite is progenitor/stem cells. Few studies have shown that simple use of a membrane barrier and/or bone graft following surgery might not produce adequate tissue regeneration. Literature clearly shows that few substitutes are capable of generating progenitor/stem cells and induce the undifferentiated mesenchymal cells to differentiate. Hence, this review is intended to throw light on whether tissue regeneration with the aid of bone grafts coupled with a membrane barrier will suffice or is there a need for recruiting progenitor/stem cells.