Evaluation of Single-Cell Cytokine Secretion and Cell-Cell Interactions with a Hierarchical Loading Microwell Chip

Summary: Comprehensive evaluation of single T cell functions such as cytokine secretion and cytolysis of target cells is greatly needed in adoptive cell therapy (ACT) but has never been fully fulfilled by current approaches. Herein, we develop a hierarchical loading microwell chip (HL-Chip) that ali...

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Bibliographic Details
Main Authors: Yufu Zhou, Ning Shao, Ricardo Bessa de Castro, Pengchao Zhang, Yuan Ma, Xin Liu, Feizhou Huang, Rong-Fu Wang, Lidong Qin
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305234