Direct imaging of the circular chromosome in a live bacterium
Bacterial chromosomes are tightly packed, limiting structural analysis by imaging techniques. Here, by quantitative time-lapse single-cell imaging of widened Escherichia coli cells, Wu and Japaridze et al. show that the chromosome exhibits a ring-like torus topology and a dynamic domain structure.
Main Authors: | Fabai Wu, Aleksandre Japaridze, Xuan Zheng, Jakub Wiktor, Jacob W. J. Kerssemakers, Cees Dekker |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-10221-0 |
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