LIG4 mediates Wnt signalling-induced radioresistance
The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically medi...
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Bibliographic Details
| Main Authors: |
Sohee Jun,
Youn-Sang Jung,
Han Na Suh,
Wenqi Wang,
Moon Jong Kim,
Young Sun Oh,
Esther M. Lien,
Xi Shen,
Yoshihisa Matsumoto,
Pierre D. McCrea,
Lei Li,
Junjie Chen,
Jae-Il Park |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10994
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