The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto’s Thyroiditis: An in Vitro Model of Thyroid Autoimmunity

The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto’s Thyroiditis: An in Vitro Model of Thyroid Autoimmunity

Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are involved in destruction of thyroid tissue in Hashimoto&#8217;s thyroiditis (HT). <i>N</i>-glycosylation of the Fc fragment affects the effector functions of IgG by enhancing or suppre...

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Bibliographic Details
Main Authors: Marta Ząbczyńska, Katarzyna Polak, Kamila Kozłowska, Grzegorz Sokołowski, Ewa Pocheć
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
igg
<i>n</i>-glycosylation
sialylation
antibody-dependent cell-mediated cytotoxicity (adcc)
complement-dependent cyttoxicity (cdc)
hashimoto’s thyroiditis
Online Access:https://www.mdpi.com/2218-273X/10/2/171

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