Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

Transforming growth factor-β (TGF-β) suppresses innate and adaptive immune responses via multiple mechanisms. TGF-β also importantly contributes to the formation of an immunosuppressive tumor microenvironment thereby promoting tumor growth. Amongst others, TGF-β impairs tumor recognition by cytotoxi...

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Bibliographic Details
Main Authors: Mariya Lazarova, Alexander Steinle
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
NK cell
NKG2D
TGF-β1
tumor immune evasion
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02689/full

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