LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.

Bibliographic Details
Main Authors:	Min Wu, Yan Chang, Huaibin Hu, Rui Mu, Yucheng Zhang, Xuanhe Qin, Xiaotao Duan, Weihua Li, Haiqing Tu, Weina Zhang, Guang Wang, Qiuying Han, Ailing Li, Tao Zhou, Kazuhiro Iwai, Xuemin Zhang, Huiyan Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08043-7

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spelling	doaj-5809cafc35ca4635be9bb6eaa78f6d832021-05-11T11:52:30ZengNature Publishing GroupNature Communications2041-17232019-01-0110111510.1038/s41467-018-08043-7LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochoresMin Wu0Yan Chang1Huaibin Hu2Rui Mu3Yucheng Zhang4Xuanhe Qin5Xiaotao Duan6Weihua Li7Haiqing Tu8Weina Zhang9Guang Wang10Qiuying Han11Ailing Li12Tao Zhou13Kazuhiro Iwai14Xuemin Zhang15Huiyan Li16State Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisDepartment of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisDuring cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.https://doi.org/10.1038/s41467-018-08043-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Min Wu Yan Chang Huaibin Hu Rui Mu Yucheng Zhang Xuanhe Qin Xiaotao Duan Weihua Li Haiqing Tu Weina Zhang Guang Wang Qiuying Han Ailing Li Tao Zhou Kazuhiro Iwai Xuemin Zhang Huiyan Li
spellingShingle	Min Wu Yan Chang Huaibin Hu Rui Mu Yucheng Zhang Xuanhe Qin Xiaotao Duan Weihua Li Haiqing Tu Weina Zhang Guang Wang Qiuying Han Ailing Li Tao Zhou Kazuhiro Iwai Xuemin Zhang Huiyan Li LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores Nature Communications
author_facet	Min Wu Yan Chang Huaibin Hu Rui Mu Yucheng Zhang Xuanhe Qin Xiaotao Duan Weihua Li Haiqing Tu Weina Zhang Guang Wang Qiuying Han Ailing Li Tao Zhou Kazuhiro Iwai Xuemin Zhang Huiyan Li
author_sort	Min Wu
title	LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_short	LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_full	LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_fullStr	LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_full_unstemmed	LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_sort	lubac controls chromosome alignment by targeting cenp-e to attached kinetochores
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.
url	https://doi.org/10.1038/s41467-018-08043-7
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LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

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