Metabolic and Molecular Mechanisms of Macrophage Polarisation and Adipose Tissue Insulin Resistance

Metabolic and Molecular Mechanisms of Macrophage Polarisation and Adipose Tissue Insulin Resistance

Inflammation plays a key role in the development and progression of type-2 diabetes (T2D), a disease characterised by peripheral insulin resistance and systemic glucolipotoxicity. Visceral adipose tissue (AT) is the main source of inflammation early in the disease course. Macrophages are innate immu...

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Bibliographic Details
Main Authors: Lucie Orliaguet, Tina Ejlalmanesh, Fawaz Alzaid
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
adipose tissue
inflammation
insulin resistance
immunometabolism
macrophages
type-2 diabetes
Online Access:https://www.mdpi.com/1422-0067/21/16/5731

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