Effect of type II diabetes mellitus on treatment outcomes of tuberculosis

Context: There is conflicting evidence of effect of diabetes on treatment of tuberculosis (TB). There is a need to investigate effect of diabetes on outcomes of TB treatment under field conditions in India. Aims: To compare treatment outcomes among TB patients with diabetes with those without diabet...

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Main Authors: Aswin Amalavathy Viswanathan, Nilesh Chandrakant Gawde
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Lung India
Subjects:
Online Access:http://www.lungindia.com/article.asp?issn=0970-2113;year=2014;volume=31;issue=3;spage=244;epage=248;aulast=Viswanathan
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spelling doaj-57f40ba8478f4116a56a8d06edcedfdc2020-11-25T01:11:36ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2014-01-0131324424810.4103/0970-2113.135764Effect of type II diabetes mellitus on treatment outcomes of tuberculosisAswin Amalavathy ViswanathanNilesh Chandrakant GawdeContext: There is conflicting evidence of effect of diabetes on treatment of tuberculosis (TB). There is a need to investigate effect of diabetes on outcomes of TB treatment under field conditions in India. Aims: To compare treatment outcomes among TB patients with diabetes with those without diabetes. Setting and Design: Study was conducted in Cuddalore, Tamil Nadu, among patients registered with Revised National TB Control Programme. Prospective observational study design was used. Materials and Methods: Registered TB patients aged 30 and above were invited to participate in the study. Those who were not aware of their diabetic status were diagnosed using oral glucose tolerance test. A total of 89 diabetic and 120 non-diabetic patients were recruited in the study. They were followed up till the end of treatment and outcomes were recorded. Statistical Analysis Used: Treatment outcomes in the two groups were compared using bi-variate and multi-variate analysis. Results: Bi-variate (unadjusted) analysis showed similar treatment success rates in the two groups. But, the adjusted odds ratios for successful treatment among diabetic patients were significantly lower (0.191, 95% CI 0.04-0.90) for pulmonary TB patients and for smear positive pulmonary TB patients (odds ration 0.099, 0.013-0.761). Diabetes was found to be predictor for sputum positivity at end of treatment. Conclusions: Diabetes increases risk of poor treatment outcomes among pulmonary TB patients. The study highlights need of screening of TB patients for diabetes. There is need to see the effect of glycemic control on treatment outcomes among diabetics.http://www.lungindia.com/article.asp?issn=0970-2113;year=2014;volume=31;issue=3;spage=244;epage=248;aulast=ViswanathanDiabetestreatment outcomestuberculosis
collection DOAJ
language English
format Article
sources DOAJ
author Aswin Amalavathy Viswanathan
Nilesh Chandrakant Gawde
spellingShingle Aswin Amalavathy Viswanathan
Nilesh Chandrakant Gawde
Effect of type II diabetes mellitus on treatment outcomes of tuberculosis
Lung India
Diabetes
treatment outcomes
tuberculosis
author_facet Aswin Amalavathy Viswanathan
Nilesh Chandrakant Gawde
author_sort Aswin Amalavathy Viswanathan
title Effect of type II diabetes mellitus on treatment outcomes of tuberculosis
title_short Effect of type II diabetes mellitus on treatment outcomes of tuberculosis
title_full Effect of type II diabetes mellitus on treatment outcomes of tuberculosis
title_fullStr Effect of type II diabetes mellitus on treatment outcomes of tuberculosis
title_full_unstemmed Effect of type II diabetes mellitus on treatment outcomes of tuberculosis
title_sort effect of type ii diabetes mellitus on treatment outcomes of tuberculosis
publisher Wolters Kluwer Medknow Publications
series Lung India
issn 0970-2113
0974-598X
publishDate 2014-01-01
description Context: There is conflicting evidence of effect of diabetes on treatment of tuberculosis (TB). There is a need to investigate effect of diabetes on outcomes of TB treatment under field conditions in India. Aims: To compare treatment outcomes among TB patients with diabetes with those without diabetes. Setting and Design: Study was conducted in Cuddalore, Tamil Nadu, among patients registered with Revised National TB Control Programme. Prospective observational study design was used. Materials and Methods: Registered TB patients aged 30 and above were invited to participate in the study. Those who were not aware of their diabetic status were diagnosed using oral glucose tolerance test. A total of 89 diabetic and 120 non-diabetic patients were recruited in the study. They were followed up till the end of treatment and outcomes were recorded. Statistical Analysis Used: Treatment outcomes in the two groups were compared using bi-variate and multi-variate analysis. Results: Bi-variate (unadjusted) analysis showed similar treatment success rates in the two groups. But, the adjusted odds ratios for successful treatment among diabetic patients were significantly lower (0.191, 95% CI 0.04-0.90) for pulmonary TB patients and for smear positive pulmonary TB patients (odds ration 0.099, 0.013-0.761). Diabetes was found to be predictor for sputum positivity at end of treatment. Conclusions: Diabetes increases risk of poor treatment outcomes among pulmonary TB patients. The study highlights need of screening of TB patients for diabetes. There is need to see the effect of glycemic control on treatment outcomes among diabetics.
topic Diabetes
treatment outcomes
tuberculosis
url http://www.lungindia.com/article.asp?issn=0970-2113;year=2014;volume=31;issue=3;spage=244;epage=248;aulast=Viswanathan
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