Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.

Bibliographic Details
Main Authors:	Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04127-6

id	doaj-57ecee0efcf14d1483faaa10d2a4a7bd
record_format	Article
spelling	doaj-57ecee0efcf14d1483faaa10d2a4a7bd2021-05-11T10:01:37ZengNature Publishing GroupNature Communications2041-17232018-05-019111510.1038/s41467-018-04127-6Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and functionLenan Zhuang0Younghoon Jang1Young-Kwon Park2Ji-Eun Lee3Shalini Jain4Eugene Froimchuk5Aaron Broun6Chengyu Liu7Oksana Gavrilova8Kai Ge9Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHAdipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHAdipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHAdipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHMouse Metabolism Core Laboratory, National Institute of Diabetes, Digestive and Kidney Diseases, NIHAdipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHAdipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHTransgenic Core, National Heart, Lung, and Blood Institute, NIHMouse Metabolism Core Laboratory, National Institute of Diabetes, Digestive and Kidney Diseases, NIHAdipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIHThe epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.https://doi.org/10.1038/s41467-018-04127-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lenan Zhuang Younghoon Jang Young-Kwon Park Ji-Eun Lee Shalini Jain Eugene Froimchuk Aaron Broun Chengyu Liu Oksana Gavrilova Kai Ge
spellingShingle	Lenan Zhuang Younghoon Jang Young-Kwon Park Ji-Eun Lee Shalini Jain Eugene Froimchuk Aaron Broun Chengyu Liu Oksana Gavrilova Kai Ge Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function Nature Communications
author_facet	Lenan Zhuang Younghoon Jang Young-Kwon Park Ji-Eun Lee Shalini Jain Eugene Froimchuk Aaron Broun Chengyu Liu Oksana Gavrilova Kai Ge
author_sort	Lenan Zhuang
title	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_short	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_full	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_fullStr	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_full_unstemmed	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_sort	depletion of nsd2-mediated histone h3k36 methylation impairs adipose tissue development and function
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.
url	https://doi.org/10.1038/s41467-018-04127-6
work_keys_str_mv	AT lenanzhuang depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT younghoonjang depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT youngkwonpark depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT jieunlee depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT shalinijain depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT eugenefroimchuk depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT aaronbroun depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT chengyuliu depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT oksanagavrilova depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction AT kaige depletionofnsd2mediatedhistoneh3k36methylationimpairsadiposetissuedevelopmentandfunction
_version_	1721448827444002816

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

Similar Items