Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.

Bibliographic Details
Main Authors: Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04127-6
Description
Summary:The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.
ISSN:2041-1723

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