Single- and multiple-dose pharmacokinetics of ethambutol and rifampicin in a tuberculosis patient with acute respiratory distress syndrome undergoing extended daily dialysis and ECMO treatment

Single- and multiple-dose pharmacokinetics of ethambutol and rifampicin in a tuberculosis patient with acute respiratory distress syndrome undergoing extended daily dialysis and ECMO treatment

The dosing of drugs in critically ill patients undergoing renal replacement therapy is based on limited data. We report for the first time single- and multiple-dose pharmacokinetics of ethambutol (EMB), which is cleared renally to 80%, and rifampicin (RIF), which is cleared renally to <30%, in a...

Full description

Bibliographic Details
Main Authors: Ann-Kathrin Strunk, Sandra Ciesek, Julius J. Schmidt, Christian Kühn, Marius M. Hoeper, Tobias Welte, Jan T. Kielstein
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:International Journal of Infectious Diseases
Subjects:
Active tuberculosis
Ethambutol
Rifampicin
Renal replacement therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971215002520

Internet

http://www.sciencedirect.com/science/article/pii/S1201971215002520

Similar Items