Activation of Toll-like receptor-9 promotes cellular migration via up-regulating MMP-2 expression in oral squamous cell carcinoma.

Activation of Toll-like receptor-9 promotes cellular migration via up-regulating MMP-2 expression in oral squamous cell carcinoma.

PURPOSE: Activation of Toll like receptors (TLRs) signaling has been implicated in promoting malignant cell invasion and metastatic potential. Previously we demonstrated that increased TLR-9 expression predicted poor survival in oral cancer patients. The objective of this study is to further investi...

Full description

Bibliographic Details
Main Authors:	Min Ruan, Zun Zhang, Siyi Li, Min Yan, Shengwen Liu, Wenjun Yang, Lizheng Wang, Chenping Zhang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3962433?pdf=render

Similar Items

Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma
by: Anderson H. Webb, et al.
Published: (2017-06-01)

BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9
by: Chou-Kit Chou, et al.
Published: (2015-07-01)

Helicobacter pylori DNA promotes cellular proliferation, migration, and invasion of gastric cancer by activating toll-like receptor 9
by: Xiang-Rong Qin, et al.
Published: (2019-01-01)

miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
by: Ling-Fei Jia, et al.
Published: (2014-01-01)

Immunohistochemical Study of Metalloproteinases (MMP-2 and MMP-9) Expression in Laryngeal Squamous Cell Carcinoma
by: Zeinab Yehia Abdel-Meguid, et al.
Published: (2019-07-01)

Toll-Like Receptor 9 Agonists in Cancer
by: Karapetyan L, et al.
Published: (2020-10-01)

Toll-like Receptor 9 in Breast Cancer
by: Katri eSelander, et al.
Published: (2014-07-01)

THE ROLE OF TOLL-LIKE RECEPTOR 9 IN PERIODONTITIS
by: Kim, Paul
Published: (2014)

Cellular and Biochemical Events in Toll-like Receptor Signaling
by: Bonham, Kevin Scott
Published: (2014)

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 Pathway.
by: Mingcui Xu, et al.
Published: (2016-01-01)

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration
by: Jian Song, et al.
Published: (2015-02-01)

Can MMP-9 be a Prognosticator Marker for Oral Squamous Cell Carcinoma?
by: Betina Chandolia, et al.
Published: (2016-01-01)

WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating β-Catenin/MMP9-Mediated Signaling
by: Hui Xie, et al.
Published: (2020-02-01)

Toll-like receptors and cancer, particularly oral squamous cell carcinoma
by: Alison Mary Rich, et al.
Published: (2014-09-01)

Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions
by: Virgilijus Uloza, et al.
Published: (2015-03-01)

Prognostic Significance of MMP2 and MMP9 Functional Promoter Single Nucleotide Polymorphisms in Head and Neck Squamous Cell Carcinoma
by: Samaneh Hajihoseini, et al.
Published: (2011-03-01)

Toll-Like Receptors in Liver Fibrosis: cellular crosstalk and mechanisms
by: Ling eYang, et al.
Published: (2012-05-01)

Molecular and cellular dynamics of the Toll-like receptor 4 pathway.
by: Nick eGay, et al.
Published: (2014-10-01)

Toll-Like Receptor 9 Agonists for Cancer Therapy
by: Davide Melisi, et al.
Published: (2014-08-01)

Toll-like receptor 9 in alimentary tract cancers
by: Kauppila, J. (Joonas)
Published: (2014)

Macrophage morphological plasticity and migration is Rac signalling and MMP9 dependant
by: Jana Travnickova, et al.
Published: (2021-05-01)

Toll-like receptor 9 is required for opioid-induced microglia apoptosis.
by: Lei He, et al.
Published: (2011-04-01)

A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability
by: Bing Xia, et al.
Published: (2019-12-01)

Nuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonists
by: Yamazaki Tomohiko, et al.
Published: (2011-09-01)

Role of Toll like receptor in progression and suppression of oral squamous cell carcinoma
by: Yash Sharma, et al.
Published: (2020-05-01)

NEU1 SIALIDASE AND MATRIX METALLOPROTEINASE-9 CROSS-TALK IS ESSENTIAL FOR TOLL-LIKE RECEPTOR ACTIVATION AND CELLULAR SIGNALING
by: Abdulkhalek, SAMAR
Published: (2013)

Inhibition of cancer cell migration with CuS@mSiO2-PEG nanoparticles by repressing MMP-2/MMP-9 expression
by: Deng G, et al.
Published: (2017-12-01)

The role of toll-like receptor 9 in chronic stress-induced apoptosis in macrophage.
by: Yanxiao Xiang, et al.
Published: (2015-01-01)

Transcription Factor SOX5 Promotes the Migration and Invasion of Fibroblast-Like Synoviocytes in Part by Regulating MMP-9 Expression in Collagen-Induced Arthritis
by: Yumeng Shi, et al.
Published: (2018-04-01)

Matrix metalloproteinase‐14 (MMP‐14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation
by: Nanzheng Chen, et al.
Published: (2020-11-01)

Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.
by: Linda M Bradley, et al.
Published: (2012-01-01)

Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists
by: Amanda B. Macedo, et al.
Published: (2019-10-01)

Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9
by: Tamiko Ishizu, et al.
Published: (2021-09-01)

Emerging roles of Toll-like receptor 9 in cardiometabolic disorders
by: Sachiko Nishimoto, et al.
Published: (2020-07-01)

Toll-like receptor 9 mediated responses in cardiac fibroblasts.
by: Ingrid Kristine Ohm, et al.
Published: (2014-01-01)

Mannan-binding lectin inhibits Candida albicans-induced cellular responses in PMA-activated THP-1 cells through Toll-like receptor 2 and Toll-like receptor 4.
by: Mingyong Wang, et al.
Published: (2013-01-01)

Receptor syndecan-1 controls MMP-9 expression during keratinocyte migration
by: Michopoulou, Anna
Published: (2016)

Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: relationships and prognostic implications
by: Fan Hai-Xia, et al.
Published: (2012-10-01)

TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells
by: Hirari Yamahana, et al.
Published: (2021-09-01)

Lutein Treatment Effects on the Redox Status and Metalloproteinase–9 (MMP-9) in Oral Cancer Squamous Cells—Are There Therapeutical Hopes?
by: Dan Alexandru Enășescu, et al.
Published: (2021-05-01)