Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis

Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis

Background: Due to the aggressive clinical behavior, poor outcome, and lack of effective specific targeted therapies, triple-negative breast cancer (TNBC) has currently been recognized as one of the most malignant types of tumors. In the present study, we investigated the cytotoxic effect of ziyugly...

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Bibliographic Details
Main Authors: Xue Zhu, Ke Wang, Kai Zhang, Ting Zhang, Yongxiang Yin, Fei Xu
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
ziyuglycoside I
MDA-MB-231 cell line
G2/M phase arrest
intrinsic and extrinsic apoptosis
Online Access:http://www.mdpi.com/1422-0067/17/11/1903

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http://www.mdpi.com/1422-0067/17/11/1903

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