Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda

Abstract Background In 2012, the World Health Organization recommended that pregnant women in malaria-endemic countries complete at least three (optimal) doses of intermittent preventive treatment (IPTp) using sulfadoxine-pyrimethamine (SP) to prevent malaria and related adverse events during pregna...

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Main Authors: Mbonye K. Martin, Kirwana B. Venantius, Ndugga Patricia, Kikaire Bernard, Baleeta Keith, Kabagenyi Allen, Asiimwe Godfrey, Twesigye Rogers, Kadengye T. Damazo, Byonanebye M. Dathan
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Malaria Journal
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12936-020-03230-8
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spelling doaj-57c8d89c188942dcb4534c1f88dcca2a2020-11-25T03:01:00ZengBMCMalaria Journal1475-28752020-04-0119111410.1186/s12936-020-03230-8Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central UgandaMbonye K. Martin0Kirwana B. Venantius1Ndugga Patricia2Kikaire Bernard3Baleeta Keith4Kabagenyi Allen5Asiimwe Godfrey6Twesigye Rogers7Kadengye T. Damazo8Byonanebye M. Dathan9Department of Population Studies, School of Statistics and Planning, College of Business and Management Sciences, Makerere UniversityMildmayDepartment of Population Studies, School of Statistics and Planning, College of Business and Management Sciences, Makerere UniversityDepartment of Pediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere UniversityUniversity Research Co., LLCDepartment of Population Studies, School of Statistics and Planning, College of Business and Management Sciences, Makerere UniversityReformed Theological CollegeUniversity Research Co., LLCAfrican Population and Health Research CentreDepartment of Community and Behavioral Sciences, School of Public Health, College of Health Sciences, Makerere UniversityAbstract Background In 2012, the World Health Organization recommended that pregnant women in malaria-endemic countries complete at least three (optimal) doses of intermittent preventive treatment (IPTp) using sulfadoxine-pyrimethamine (SP) to prevent malaria and related adverse events during pregnancy. Uganda adopted this recommendation, but uptake remains low in East-Central and information to explain this low uptake remains scanty. This analysis determined correlates of uptake of optimal doses of IPTp-SP in East-Central Uganda. Methods This was a secondary analysis of the 2016 Uganda Demographic Health Survey data on 579 women (15–49 years) who attended at least one antenatal care (ANC) visit and had a live birth within 2 years preceding the survey. Uptake of IPTp-SP was defined as optimal if a woman received at least three doses; partial if they received 1–2 doses or none if they received no dose. Multivariate analysis using multinomial logistic regression was used to determine correlates of IPTp-SP uptake. Results Overall, 22.3% of women received optimal doses of IPTp-SP, 48.2% partial and 29.5% none. Attending ANC at a lower-level health centre relative to a hospital was associated with reduced likelihood of receiving optimal doses of IPTp-SP. Belonging to other religious faiths relative to Catholic, belonging to a household in the middle relative to poorest wealth index, and age 30 and above years relative to 25–29 years were associated with higher likelihood of receiving optimal doses of IPTp-SP. Conclusions In East-Central Uganda, uptake of optimal doses of IPTp-SP is very low. Improving institutional delivery and household wealth, involving religious leaders in programmes to improve uptake of IPTp-SP, and strengthening IPTp-SP activities at lower level health centers may improve uptake of IPTp-SP in the East-Central Uganda.http://link.springer.com/article/10.1186/s12936-020-03230-8Intermittent preventive treatment during pregnancyMalariaUgandaDemographic and health survey
collection DOAJ
language English
format Article
sources DOAJ
author Mbonye K. Martin
Kirwana B. Venantius
Ndugga Patricia
Kikaire Bernard
Baleeta Keith
Kabagenyi Allen
Asiimwe Godfrey
Twesigye Rogers
Kadengye T. Damazo
Byonanebye M. Dathan
spellingShingle Mbonye K. Martin
Kirwana B. Venantius
Ndugga Patricia
Kikaire Bernard
Baleeta Keith
Kabagenyi Allen
Asiimwe Godfrey
Twesigye Rogers
Kadengye T. Damazo
Byonanebye M. Dathan
Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda
Malaria Journal
Intermittent preventive treatment during pregnancy
Malaria
Uganda
Demographic and health survey
author_facet Mbonye K. Martin
Kirwana B. Venantius
Ndugga Patricia
Kikaire Bernard
Baleeta Keith
Kabagenyi Allen
Asiimwe Godfrey
Twesigye Rogers
Kadengye T. Damazo
Byonanebye M. Dathan
author_sort Mbonye K. Martin
title Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda
title_short Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda
title_full Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda
title_fullStr Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda
title_full_unstemmed Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda
title_sort correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in east-central uganda
publisher BMC
series Malaria Journal
issn 1475-2875
publishDate 2020-04-01
description Abstract Background In 2012, the World Health Organization recommended that pregnant women in malaria-endemic countries complete at least three (optimal) doses of intermittent preventive treatment (IPTp) using sulfadoxine-pyrimethamine (SP) to prevent malaria and related adverse events during pregnancy. Uganda adopted this recommendation, but uptake remains low in East-Central and information to explain this low uptake remains scanty. This analysis determined correlates of uptake of optimal doses of IPTp-SP in East-Central Uganda. Methods This was a secondary analysis of the 2016 Uganda Demographic Health Survey data on 579 women (15–49 years) who attended at least one antenatal care (ANC) visit and had a live birth within 2 years preceding the survey. Uptake of IPTp-SP was defined as optimal if a woman received at least three doses; partial if they received 1–2 doses or none if they received no dose. Multivariate analysis using multinomial logistic regression was used to determine correlates of IPTp-SP uptake. Results Overall, 22.3% of women received optimal doses of IPTp-SP, 48.2% partial and 29.5% none. Attending ANC at a lower-level health centre relative to a hospital was associated with reduced likelihood of receiving optimal doses of IPTp-SP. Belonging to other religious faiths relative to Catholic, belonging to a household in the middle relative to poorest wealth index, and age 30 and above years relative to 25–29 years were associated with higher likelihood of receiving optimal doses of IPTp-SP. Conclusions In East-Central Uganda, uptake of optimal doses of IPTp-SP is very low. Improving institutional delivery and household wealth, involving religious leaders in programmes to improve uptake of IPTp-SP, and strengthening IPTp-SP activities at lower level health centers may improve uptake of IPTp-SP in the East-Central Uganda.
topic Intermittent preventive treatment during pregnancy
Malaria
Uganda
Demographic and health survey
url http://link.springer.com/article/10.1186/s12936-020-03230-8
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