Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer

Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer

Primary androgen ablation leads to symptomatic improvement and a reduction in prostate-specific antigen (PSA) serum levels in patients with advanced prostate cancer, but all patients eventually become refractory to hormone therapy with progression of the disease and a life expectancy of about a year...

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Bibliographic Details
Main Authors: Tal Grenader, Anthony Goldberg
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2010.163
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spelling doaj-57be31095d774e46b615a700824f921f2020-11-25T02:19:31ZengHindawi LimitedThe Scientific World Journal1537-744X2010-01-01101814181710.1100/tsw.2010.163Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate CancerTal Grenader0Anthony Goldberg1Department of Oncology, Sha'are Zedek Medical Center, Jerusalem, IsraelDepartment of Oncology, Sha'are Zedek Medical Center, Jerusalem, IsraelPrimary androgen ablation leads to symptomatic improvement and a reduction in prostate-specific antigen (PSA) serum levels in patients with advanced prostate cancer, but all patients eventually become refractory to hormone therapy with progression of the disease and a life expectancy of about a year. We describe a patient who developed castration resistance, was treated with vinorelbine, and continues to be progression free on therapy with luteinizing hormone releasing hormone agonists alone, more than 2.5 years following cessation of treatment with vinorelbine.http://dx.doi.org/10.1100/tsw.2010.163
collection DOAJ
language English
format Article
sources DOAJ
author Tal Grenader
Anthony Goldberg
spellingShingle Tal Grenader
Anthony Goldberg
Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer
The Scientific World Journal
author_facet Tal Grenader
Anthony Goldberg
author_sort Tal Grenader
title Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer
title_short Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer
title_full Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer
title_fullStr Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer
title_full_unstemmed Reinduction of Hormone Sensitivity to Goserelin following Chemotherapy with Vinorelbine in Castration-Resistant Prostate Cancer
title_sort reinduction of hormone sensitivity to goserelin following chemotherapy with vinorelbine in castration-resistant prostate cancer
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2010-01-01
description Primary androgen ablation leads to symptomatic improvement and a reduction in prostate-specific antigen (PSA) serum levels in patients with advanced prostate cancer, but all patients eventually become refractory to hormone therapy with progression of the disease and a life expectancy of about a year. We describe a patient who developed castration resistance, was treated with vinorelbine, and continues to be progression free on therapy with luteinizing hormone releasing hormone agonists alone, more than 2.5 years following cessation of treatment with vinorelbine.
url http://dx.doi.org/10.1100/tsw.2010.163
work_keys_str_mv AT talgrenader reinductionofhormonesensitivitytogoserelinfollowingchemotherapywithvinorelbineincastrationresistantprostatecancer
AT anthonygoldberg reinductionofhormonesensitivitytogoserelinfollowingchemotherapywithvinorelbineincastrationresistantprostatecancer
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