Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ) degradation and subsequent dermal invasion are the earliest steps of melanoma dissemination, but the mechanisms remain elusive. We previously identified Tspan8 as a key actor in mel...

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Bibliographic Details
Main Authors: Manale El Kharbili, Muriel Cario, Nicolas Béchetoille, Catherine Pain, Claude Boucheix, Françoise Degoul, Ingrid Masse, Odile Berthier-Vergnes
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
tumor microenvironment
melanoma invasion
melanoma-keratinocytes crosstalk
dermal-epidermal junction
dermis
Tetraspanin 8
Online Access:https://www.mdpi.com/2072-6694/12/5/1297

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https://www.mdpi.com/2072-6694/12/5/1297

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