Nifedipine-retard alone and incombination with metoprolol: comparative efficacy andsafety in patients with arterial hypertension

• Main Authors: O Yu Isaikina, V M Gorbunov, G F Andreeva, N A Dmitrieva, S Yu Martsevich
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2003-12-01
• Series: Терапевтический архив
• Subjects: calcium antagonists; nifedipinretard; metoprolol; 24-h monitoring of arterial pressure; arterial hypertension
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/29704

Aim. To compare efficacy and safety of nifedipin-retard (cordaflex-retard, Egis, Hungary) used in monotherapy and in combination with metoprolol (egilok, Egis, Hungary) in patients with arterial hypertension (AH). Material and methods. The study included 20 patients with AH stage I-II (12 males, 8 females, mean age 57.3 years, mean duration of the disease 8.6 years). Nifedipin-retard was given in a daily dose 40 mg/day (20 mg twice a day) in monotherapy and 20 mg/day in combination with metoprolol which was administered 50 mg twice a day (a daily dose 100 mg/day). The control examination consisted of a physical examination, measurement of arterial pressure (AP) by Korotkov, registration of heart rate, ECG, 24-h AP monitoring, echocardiography. Results. By 24-h AP monitoring, a 4-week treatment with nifedipin-retard alone resulted in lowering of systolic arterial pressure. The combined treatment produced a more pronounced fall both in systolic and diastolic pressure. Diastolic left-ventricular function improved in combined therapy. Side effects observed in nifedipin-retard monotherapy got much more weaker when this drug combined with metoprolol. Conclusion. Combination of nifedipin-retard with metoprolol provides better clinical response and tolerance than monotherapy with nifedipin-retard.