Significance of hepatic fibrosis markers in early diagnosis of type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease

• Main Authors: Lei-Qun Lu, Ye-Li Zhang, Ying Shen
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-07-01
• Series: Journal of Hainan Medical University
• Subjects: type tow diabetes; nonalcoholic fatty liver disease; hyaluronic acid; laminin; collagen iv
• Online Access: http://www.hnykdxxb.com/PDF/201913/04.pdf
• ISSN: 1007-1237; 1007-1237

Objective: Hyaluronic acid (HA), laminin (LN), and collagen IV (CIV) are major serum markers of liver fibrosis. This study evaluated the diagnostic value of various noninvasive indicators for hepatic fibrosis in patients with T2DM and NAFLD. Methods: Between January 2016 and September 2018, a total of 278 patients, which were grouped to normal, NAFLD and T2DM with NAFLD. Routine clinical and laboratory examinations were collected, including age, sex, blood routine, HbA1C, FBG, FCP, AST, AST, ALB, PLT, TC, TG, HDL, LDL, serum fibrosis C-IV, HA, LN. NFS, APRI and FIB4 scores were calculated. Results: No statistical difference was found on age, ALT, AST, GGT, BMI, TG, CHOL, and Glu, APRI, FIB4, CIV, LN, and HA exhibited statistical significance. Further correlation analysis showed that HA, IV-C, LN, were positively correlated with NFS, APRI, and FIB4. Conclusions: Compared with healthy control group, ALT, AST, TC, TG, HDL and LDL in NAFLD group, T2DM patients with NAFLD group increased to different degrees, and the difference was statistically significant. The HA, C-IV, LN, NFS, APRI ratio index and FIB-4 index of T2DM patients with NAFLD were higher than those of NAFLD group and healthy control group, and the HA, C-IV and LN of NAFLD group were higher than those of healthy control group. Compared with non-fibrosis group, HA, LN, C-IV, ALT and AST in fibrosis group were significantly higher. Moreover, HA, LN and C-IV were positively correlated with NFS, APRI ratio index and FIB-4 index.