Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramo...
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Bibliographic Details
| Main Authors: |
Annika Meiners,
Sandra Bäcker,
Inesa Hadrović,
Christian Heid,
Christine Beuck,
Yasser B. Ruiz-Blanco,
Joel Mieres-Perez,
Marius Pörschke,
Jean-Noël Grad,
Cecilia Vallet,
Daniel Hoffmann,
Peter Bayer,
Elsa Sánchez-García,
Thomas Schrader,
Shirley K. Knauer |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21753-9
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