Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

• Main Authors: Wagener Asja, Goessling Helge F, Schmitt Armin O, Mauel Susanne, Gruber Achim D, Reinhardt Richard, Brockmann Gudrun A
• Format: Article
• Language: English
• Published: BMC 2010-09-01
• Series: Lipids in Health and Disease
• Online Access: http://www.lipidworld.com/content/9/1/99

<p>Abstract</p> <p>Background</p> <p>The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different <it>Ppar </it>genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes.</p> <p>Results</p> <p>At the age of 10 weeks, the BFMI mice exhibited marked obesity with enlarged adipocytes and high serum triglycerides concentrations in comparison to the often used mouse line C57BL/6 (B6). Between these two lines, gene expression analyses revealed differentially expressed genes belonging to the PPAR pathway, in particular genes of the lipogenesis and the fatty acid transport.</p> <p>Conclusion</p> <p>Surprisingly, the <it>Ppar-α </it>gene expression was up-regulated in liver and <it>Ppar-γ </it>gene expression was down-regulated in the white adipose tissue, indicating the activation of a mechanism that counteracts the rise of obesity.</p>