Anthelmintics – From Discovery to Resistance

• Main Authors: Adrian J. Wolstenholme, Richard J. Martin
• Format: Article
• Language: English
• Published: Elsevier 2014-12-01
• Series: International Journal for Parasitology: Drugs and Drug Resistance
• Subjects: Anthelmintics; Resistance; Drug discovery; Scientific meeting
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211320714000311

The scientific meeting entitled ‘Anthelmintics: From Discovery to Resistance’ was held in San Francisco in February 2014. The themes of the meeting were drug discovery, modes of action and resistance. Both human and veterinary parasites were covered in the oral and poster presentations. The attendees were from both academic and industrial backgrounds. In the present article we introduce a number of the papers that emerged from the meeting. Several of the papers covered current drug discovery efforts underway worldwide, with some specific examples focusing on ion channels, protein kinases and cysteine proteases. These efforts included the repurposing of known drugs as well as the discovery of novel actives. Two papers described recently-developed whole-organism screening techniques. Finally, we introduce several papers looking at mechanisms and management of drug resistance in human and veterinary parasites.