Effect of adjuvant Shuxuening injection therapy on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD

• Main Authors: Jie Li, Min Xu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Chronic obstructive pulmonary disease; Shuxuening; Toll-like receptor; Inflammatory cytokines; Airway remodeling
• Online Access: http://www.hnykdxxb.com/PDF/201704/11.pdf

Objective: To study the effect of adjuvant Shuxuening injection therapy on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD. Methods: Patients with acute exacerbation of COPD who received Shuxuening injection combined with conventional western medicine treatment in our hospital between May 2014 and December 2015 were selected for study, and before treatment as well as 1 week, 2 weeks, 3 weeks and 4 weeks after treatment, peripheral blood mononuclear cells were collected to determine TLRs expression, and serum was collected to determine the levels of inflammatory cytokines and airway remodeling molecules. Results: 1 week, 2 weeks, 3 weeks and 4 weeks after treatment, TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells as well as TNF- α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels in serum of patients with COPD were significantly lower than those before treatment, and TLR3, TLR7, TLR8 and TLR9 mRNA expression were not significantly different from those before treatment; TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells were positively correlated with serum TNF-α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels. Conclusion: Adjuvant Shuxuening injection therapy has significant inhibitory effect on the inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.