The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

Background and AimsThe development of multi-organ injury in cirrhosis is associated with increased intestinal permeability, translocation of gut-derived bacterial products [e.g., lipopolysaccharide (LPS)] into the circulation, and increased non-apoptotic hepatocyte cell death. Pyroptosis is a non-ap...

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Bibliographic Details
Main Authors: Ugo Soffientini, Nigel Beaton, Sukriti Baweja, Emmanuel Weiss, Chhagan Bihari, Abeba Habtesion, Vishal Patel, Valerie Paradis, Archana Sharma, Tu Vinh Luong, Andrew Hall, Aida Nadar, Shiv Sarin, Shilpa Chokshi, Roger Williams, Benedicte Py, Richard Moreau, Rajiv Jalan, Gautam Mehta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cirrhosis
lipopolysaccharide
caspase
liver failure
endotoxin
dysbiosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.668459/full

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