EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression

EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression

DNA mismatch repair (MMR) function is critical for correcting errors coincident with polymerase-driven DNA replication, and its proteins are frequent targets for inactivation (germline or somatic), generating a hypermutable tumor that drives cancer progression. The biomarker for defective DNA MMR is...

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Bibliographic Details
Main Authors:	John M. Carethers, Minoru Koi, Stephanie S. Tseng-Rogenski
Format:	Article
Language:	English
Published:	MDPI AG 2015-03-01
Series:	Genes
Subjects:	DNA mismatch repair microsatellite instability genomic instability colorectal cancer MSH3 MutSβ inflammation short tandem repeats EMAST patient survival patient outcome
Online Access:	http://www.mdpi.com/2073-4425/6/2/185

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