A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells

A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells

Naphthyridine derivatives are a widely-used class of heterocycles due to their pharmacological activities. A novel compound (10-Methoxy-1,2,3,4-tetrahydrobenzo(g)(1,3) diazepino(1,2-a)-(1,8)naphthyridin-6-yl)(phenyl) methanone (named 3u), showed good anticancer activity in the human malignant melano...

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Bibliographic Details
Main Authors: Qinghong Kong, Jianxin Lv, Shengjiao Yan, Kwen-Jen Chang, Guanlin Wang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
naphthyridine derivative
death receptors
apoptosis
caspase-8
necroptosis
melanoma
Online Access:http://www.mdpi.com/1422-0067/19/10/2975

Internet

http://www.mdpi.com/1422-0067/19/10/2975

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