Establishment of lung cancer patient-derived xenograft models and primary cell lines for lung cancer study

Establishment of lung cancer patient-derived xenograft models and primary cell lines for lung cancer study

Abstract Background The overall 5-year survival rate of lung cancer is about 15% even with therapeutic drugs like tyrosine kinase inhibitors. Ideal models are urgently needed for exploring mechanisms and finding new drugs. Patient-derived xenografts (PDX) models and primary cells are both used to sc...

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Bibliographic Details
Main Authors: Yanan Jiang, Jimin Zhao, Yi Zhang, Ke Li, Tiepeng Li, Xinhuan Chen, Simin Zhao, Song Zhao, Kangdong Liu, Ziming Dong
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Translational Medicine
Subjects:
Lung cancer
Patient-derived xenograft
Signal pathway
Primary cell culture
Online Access:http://link.springer.com/article/10.1186/s12967-018-1516-5

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