<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions...

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Main Authors:	Narges Dargahi, John Matsoukas, Vasso Apostolopoulos
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Brain Sciences
Subjects:	probiotics <i>streptococcus thermophilus</i> st285 mbp<sub>83–99</sub> peptide mannan immune modulation multiple sclerosis agonist peptide
Online Access:	https://www.mdpi.com/2076-3425/10/2/126

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spelling	doaj-5793b67c8a4d4386bde94b3ecfe49aa92020-11-25T00:42:13ZengMDPI AGBrain Sciences2076-34252020-02-0110212610.3390/brainsci10020126brainsci10020126<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in MiceNarges Dargahi0John Matsoukas1Vasso Apostolopoulos2Institute for Health and Sport, Victoria University, Melbourne VIC 3030, AustraliaNewDrug, Patras Science Park, 26500 Patras, GreeceInstitute for Health and Sport, Victoria University, Melbourne VIC 3030, AustraliaProbiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions. Hence, probiotics have become prominent in recent years of investigation with regard to their health benefits. As such, in the current study, we determined the effects of <i>Streptococcus thermophilus</i> to agonist MBP<sub>83−99</sub> peptide immunized mouse spleen cells. It was noted that <i>Streptococcus thermophilus</i> induced a significant increase in the expression of anti-inflammatory IL-4, IL-5, IL-10 cytokines, and decreased the secretion of pro-inflammatory IL-1β and IFN-γ. Regular consumption of <i>Streptococcus thermophilus</i> may therefore be beneficial in the management and treatment of autoimmune diseases such as multiple sclerosis.https://www.mdpi.com/2076-3425/10/2/126probiotics<i>streptococcus thermophilus</i>st285mbp<sub>83–99</sub> peptidemannanimmune modulationmultiple sclerosisagonist peptide
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Narges Dargahi John Matsoukas Vasso Apostolopoulos
spellingShingle	Narges Dargahi John Matsoukas Vasso Apostolopoulos <i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice Brain Sciences probiotics <i>streptococcus thermophilus</i> st285 mbp<sub>83–99</sub> peptide mannan immune modulation multiple sclerosis agonist peptide
author_facet	Narges Dargahi John Matsoukas Vasso Apostolopoulos
author_sort	Narges Dargahi
title	<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice
title_short	<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice
title_full	<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice
title_fullStr	<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice
title_full_unstemmed	<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice
title_sort	<i>streptococcus</i> <i>thermophilus</i> st285 alters pro-inflammatory to anti-inflammatory cytokine secretion against multiple sclerosis peptide in mice
publisher	MDPI AG
series	Brain Sciences
issn	2076-3425
publishDate	2020-02-01
description	Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions. Hence, probiotics have become prominent in recent years of investigation with regard to their health benefits. As such, in the current study, we determined the effects of <i>Streptococcus thermophilus</i> to agonist MBP<sub>83−99</sub> peptide immunized mouse spleen cells. It was noted that <i>Streptococcus thermophilus</i> induced a significant increase in the expression of anti-inflammatory IL-4, IL-5, IL-10 cytokines, and decreased the secretion of pro-inflammatory IL-1β and IFN-γ. Regular consumption of <i>Streptococcus thermophilus</i> may therefore be beneficial in the management and treatment of autoimmune diseases such as multiple sclerosis.
topic	probiotics <i>streptococcus thermophilus</i> st285 mbp<sub>83–99</sub> peptide mannan immune modulation multiple sclerosis agonist peptide
url	https://www.mdpi.com/2076-3425/10/2/126
work_keys_str_mv	AT nargesdargahi istreptococcusiithermophilusist285altersproinflammatorytoantiinflammatorycytokinesecretionagainstmultiplesclerosispeptideinmice AT johnmatsoukas istreptococcusiithermophilusist285altersproinflammatorytoantiinflammatorycytokinesecretionagainstmultiplesclerosispeptideinmice AT vassoapostolopoulos istreptococcusiithermophilusist285altersproinflammatorytoantiinflammatorycytokinesecretionagainstmultiplesclerosispeptideinmice
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<i>Streptococcus</i> <i>thermophilus</i> ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

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