A quantitative analysis of the interplay of environment, neighborhood, and cell state in 3D spheroids
Abstract Cells react to their microenvironment by integrating external stimuli into phenotypic decisions via an intracellular signaling network. To analyze the interplay of environment, local neighborhood, and internal cell state effects on phenotypic variability, we developed an experimental approa...
Main Authors: | Vito RT Zanotelli, Matthias Leutenegger, Xiao‐Kang Lun, Fanny Georgi, Natalie de Souza, Bernd Bodenmiller |
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Format: | Article |
Language: | English |
Published: |
Wiley
2020-12-01
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Series: | Molecular Systems Biology |
Subjects: | |
Online Access: | https://doi.org/10.15252/msb.20209798 |
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