A quantitative analysis of the interplay of environment, neighborhood, and cell state in 3D spheroids

Abstract Cells react to their microenvironment by integrating external stimuli into phenotypic decisions via an intracellular signaling network. To analyze the interplay of environment, local neighborhood, and internal cell state effects on phenotypic variability, we developed an experimental approa...

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Bibliographic Details
Main Authors: Vito RT Zanotelli, Matthias Leutenegger, Xiao‐Kang Lun, Fanny Georgi, Natalie de Souza, Bernd Bodenmiller
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20209798