On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO

A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product. Some patients with cerebrotendinous xanthomatosis (CTX) and all patients w...

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Bibliographic Details
Main Authors: Ingemar Björkhem, Ulf Diczfalusy, Anita Lövgren-Sandblom, Lena Starck, Monica Jonsson, Keri Tallman, Henrik Schirmer, Lilian Bomme Ousager, Peter J. Crick, Yuqin Wang, William J. Griffiths, F. Peter Guengerich
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Journal of Lipid Research
Subjects:
cerebrotendinous xanthomatosis
Smith-Lemli-Opitz syndrome
cholesterol 7,8-epoxide
cytochrome P-450 7A1
liquid chromatography-mass spectrometryn
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352792

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http://www.sciencedirect.com/science/article/pii/S0022227520352792

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