Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

Abstract Background Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for LPA through the use of specific antibo...

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Bibliographic Details
Main Authors: Manisha Ray, Yasuyuki Kihara, Darryl J. Bornhop, Jerold Chun
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Lipids in Health and Disease
Subjects:
Lysophosphatidic acid
Compensated interferometric reader
Ligand binding
Antibody
Lpathomab
Lysophospholipid
Online Access:https://doi.org/10.1186/s12944-021-01454-4

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