Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directional...

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Main Authors: Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10430-7
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spelling doaj-57607b62c778463fae0cd13bdc1ae69b2021-05-11T11:45:31ZengNature Publishing GroupNature Communications2041-17232019-06-0110111310.1038/s41467-019-10430-7Heterochronic faecal transplantation boosts gut germinal centres in aged miceMarisa Stebegg0Alyssa Silva-Cayetano1Silvia Innocentin2Timothy P. Jenkins3Cinzia Cantacessi4Colin Gilbert5Michelle A. Linterman6Laboratory of Lymphocyte Signalling and Development, Babraham InstituteLaboratory of Lymphocyte Signalling and Development, Babraham InstituteLaboratory of Lymphocyte Signalling and Development, Babraham InstituteDepartment of Veterinary MedicineDepartment of Veterinary MedicineBiological Services Unit, Babraham InstituteLaboratory of Lymphocyte Signalling and Development, Babraham InstituteMicrobiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.https://doi.org/10.1038/s41467-019-10430-7
collection DOAJ
language English
format Article
sources DOAJ
author Marisa Stebegg
Alyssa Silva-Cayetano
Silvia Innocentin
Timothy P. Jenkins
Cinzia Cantacessi
Colin Gilbert
Michelle A. Linterman
spellingShingle Marisa Stebegg
Alyssa Silva-Cayetano
Silvia Innocentin
Timothy P. Jenkins
Cinzia Cantacessi
Colin Gilbert
Michelle A. Linterman
Heterochronic faecal transplantation boosts gut germinal centres in aged mice
Nature Communications
author_facet Marisa Stebegg
Alyssa Silva-Cayetano
Silvia Innocentin
Timothy P. Jenkins
Cinzia Cantacessi
Colin Gilbert
Michelle A. Linterman
author_sort Marisa Stebegg
title Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_short Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_full Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_fullStr Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_full_unstemmed Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_sort heterochronic faecal transplantation boosts gut germinal centres in aged mice
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.
url https://doi.org/10.1038/s41467-019-10430-7
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AT silviainnocentin heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice
AT timothypjenkins heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice
AT cinziacantacessi heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice
AT colingilbert heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice
AT michellealinterman heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice
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