Discovery and modification of cytochrome P450 for plant natural products biosynthesis

Discovery and modification of cytochrome P450 for plant natural products biosynthesis

Cytochrome P450s are widespread in nature and play key roles in the diversification and functional modification of plant natural products. Over the last few years, there has been remarkable progress in plant P450s identification with the rapid development of sequencing technology, “omics” analysis a...

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Main Authors: Xiaonan Liu, Xiaoxi Zhu, Hui Wang, Tian Liu, Jian Cheng, Huifeng Jiang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-09-01
Series:Synthetic and Systems Biotechnology
Subjects:
P450 enzymes
Plant natural products
Synthetic biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X20300429
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spelling doaj-575a339d46194e268a07b5e454ad529b2021-04-02T12:17:55ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2020-09-0153187199Discovery and modification of cytochrome P450 for plant natural products biosynthesisXiaonan Liu0Xiaoxi Zhu1Hui Wang2Tian Liu3Jian Cheng4Huifeng Jiang5Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, ChinaState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, Guangxi, 530004, China; Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, ChinaKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Corresponding author.Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Corresponding author.Cytochrome P450s are widespread in nature and play key roles in the diversification and functional modification of plant natural products. Over the last few years, there has been remarkable progress in plant P450s identification with the rapid development of sequencing technology, “omics” analysis and synthetic biology. However, challenges still persist in respect of crystal structure, heterologous expression and enzyme engineering. Here, we reviewed several research hotspots of P450 enzymes involved in the biosynthesis of plant natural products, including P450 databases, gene mining, heterologous expression and protein engineering.http://www.sciencedirect.com/science/article/pii/S2405805X20300429P450 enzymesPlant natural productsSynthetic biology
collection DOAJ
language English
format Article
sources DOAJ
author Xiaonan Liu
Xiaoxi Zhu
Hui Wang
Tian Liu
Jian Cheng
Huifeng Jiang
spellingShingle Xiaonan Liu
Xiaoxi Zhu
Hui Wang
Tian Liu
Jian Cheng
Huifeng Jiang
Discovery and modification of cytochrome P450 for plant natural products biosynthesis
Synthetic and Systems Biotechnology
P450 enzymes
Plant natural products
Synthetic biology
author_facet Xiaonan Liu
Xiaoxi Zhu
Hui Wang
Tian Liu
Jian Cheng
Huifeng Jiang
author_sort Xiaonan Liu
title Discovery and modification of cytochrome P450 for plant natural products biosynthesis
title_short Discovery and modification of cytochrome P450 for plant natural products biosynthesis
title_full Discovery and modification of cytochrome P450 for plant natural products biosynthesis
title_fullStr Discovery and modification of cytochrome P450 for plant natural products biosynthesis
title_full_unstemmed Discovery and modification of cytochrome P450 for plant natural products biosynthesis
title_sort discovery and modification of cytochrome p450 for plant natural products biosynthesis
publisher KeAi Communications Co., Ltd.
series Synthetic and Systems Biotechnology
issn 2405-805X
publishDate 2020-09-01
description Cytochrome P450s are widespread in nature and play key roles in the diversification and functional modification of plant natural products. Over the last few years, there has been remarkable progress in plant P450s identification with the rapid development of sequencing technology, “omics” analysis and synthetic biology. However, challenges still persist in respect of crystal structure, heterologous expression and enzyme engineering. Here, we reviewed several research hotspots of P450 enzymes involved in the biosynthesis of plant natural products, including P450 databases, gene mining, heterologous expression and protein engineering.
topic P450 enzymes
Plant natural products
Synthetic biology
url http://www.sciencedirect.com/science/article/pii/S2405805X20300429
work_keys_str_mv AT xiaonanliu discoveryandmodificationofcytochromep450forplantnaturalproductsbiosynthesis
AT xiaoxizhu discoveryandmodificationofcytochromep450forplantnaturalproductsbiosynthesis
AT huiwang discoveryandmodificationofcytochromep450forplantnaturalproductsbiosynthesis
AT tianliu discoveryandmodificationofcytochromep450forplantnaturalproductsbiosynthesis
AT jiancheng discoveryandmodificationofcytochromep450forplantnaturalproductsbiosynthesis
AT huifengjiang discoveryandmodificationofcytochromep450forplantnaturalproductsbiosynthesis
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