Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

Abstract Background A majority of women with polycystic ovary syndrome (PCOS) have metabolic dysfunction that results in an increased risk of type 2 diabetes. We previously developed a pubertal mouse model using the aromatase inhibitor, letrozole, which recapitulates many of the reproductive and met...

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Bibliographic Details
Main Authors: Pedro J. Torres, Danalea V. Skarra, Bryan S. Ho, Lillian Sau, Arya R. Anvar, Scott T. Kelley, Varykina G. Thackray
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Microbiology
Subjects:
Gut microbiome
Polycystic ovary syndrome
Hyperandrogenism
Puberty
Online Access:http://link.springer.com/article/10.1186/s12866-019-1425-7

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