| Summary: | Dyana Sarvasti,1 Isabella Lalenoh,2 Emanoel Oepangat,2 Budhi Setianto Purwowiyoto,3 Anwar Santoso,3 Rochmad Romdoni4 1Department of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University, Surabaya, Indonesia; 2Department of Cardiology, Siloam Hospital TB Simatupang, Jakarta, Indonesia; 3Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; 4Department of Cardiology and Vascular Medicine, Faculty of Medicine Airlangga University - Dr. Soetomo District General Hospital, Surabaya, IndonesiaCorrespondence: Dyana SarvastiDepartment of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University Jl, Raya Kalisari Selatan No. 1 Tower A, Lt. 6, Pakuwon City, Surabaya 60112, IndonesiaTel +628563000696Email dyana_sarvasti@yahoo.comPurpose: Our study aimed at determining and comparing the mechanism of cardiovascular protection variables in moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) in patients with stable coronary heart disease (CHD) after coronary stenting.Participants and Methods: This experimental study used the same subject and cross-over design, involving eleven stable CHD patients after coronary stenting. These were randomly divided into two groups; MICT for 29 minutes at 50– 60% heart rate reserve and HIIT with 4x4 minute intervals at 60– 80% heart rate reserve, each followed by three minutes of active recovery at 40– 50% heart rate reserve. These were conducted three times a week for two weeks. The participants’ levels of adrenaline, noradrenaline, endothelial nitric oxide synthase (eNOS), extracellular superoxide dismutase (EC-SOD) activity assayed, and flow-mediated dilatation (FMD) were examined before and after treatments were completed.Results: The HIIT significantly increased the levels of noradrenaline and eNOS compared with MICT (p< 0.05). Also, HIIT was better in maintaining EC-SOD activity and FMD compared with MICT (p< 0.05). Through the noradrenalin pathway, HIIT had a direct and significant effect on eNOS and FMD (p< 0.05) but MICT, through the noradrenaline pathways, had a direct and significant effect on eNOS (p< 0.05), and through the EC-SOD activity pathways had a direct and significant effect on FMD (p< 0.05). MICT reduced EC-SOD activity and also decreased the FMD value.Conclusion: HIIT is superior to MICT in increasing cardiovascular protection by increasing the concentrations of noradrenalin and eNOS, maintaining EC-SOD activity, and FMD in stable CHD patients after coronary stenting.Keywords: coronary heart disease, high-intensity interval training, catecholamine, eNOS, SOD, FMD
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