Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years. We show that human cells with extra chromosome engineere...

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Bibliographic Details
Main Authors: Maja Kneissig, Kristina Keuper, Mirjam S de Pagter, Markus J van Roosmalen, Jana Martin, Hannah Otto, Verena Passerini, Aline Campos Sparr, Ivo Renkens, Fenna Kropveld, Anand Vasudevan, Jason M Sheltzer, Wigard P Kloosterman, Zuzana Storchova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
chromosome
micronuclei
aneuploidy
chromothripsis
rearrangements
Online Access:https://elifesciences.org/articles/50292

Internet

https://elifesciences.org/articles/50292

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