LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes

LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes

In the present study, we investigated the mechanisms by which plasma lipoproteins modulate the integrin-dependent adhesion properties of monocytes. LDL induced the expression of the monocyte CD11b in vitro as well as in vivo via intracellular signaling mechanisms involving calcium transients. The ef...

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Bibliographic Details
Main Authors: Ki Hoon Han, Yiming Chen, Mi Kyung Chang, Yoon Chan Han, Jae-Hyung Park, Simone R. Green, Agnès Boullier, Oswald Quehenberger
Format: Article
Language:English
Published: Elsevier 2003-07-01
Series:Journal of Lipid Research
Subjects:
adhesion protein
atherosclerosis
CCR2
integrin
monocyte recruitment
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310956

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