Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis.

Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis.

Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in neonatal intensive care units, however its pathogenesis is not completely understood. We have previously shown that platelet activating factor (PAF), bacteria and TLR4 are all important factors in the development of NEC...

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Main Authors: Antoine Soliman, Kathrin S Michelsen, Hisae Karahashi, Jing Lu, Fan Jing Meng, Xiaowu Qu, Timothy R Crother, Shervin Rabizadeh, Shuang Chen, Michael S Caplan, Moshe Arditi, Tamas Jilling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2955554?pdf=render

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