Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method

Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method

Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a templa...

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Main Authors: Abdelmonaem Messaoudi, Hatem Belguith, Jeannette Ben Hamida
Format: Article
Language:English
Published: SAGE Publishing 2011-01-01
Series:Evolutionary Bioinformatics
Online Access:https://doi.org/10.4137/EBO.S7122
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spelling doaj-5735844627b147babe21d68b701b98072020-11-25T03:12:30ZengSAGE PublishingEvolutionary Bioinformatics1176-93432011-01-01710.4137/EBO.S7122Three-Dimensional Structure of Lipase Predicted by Homology Modeling MethodAbdelmonaem Messaoudi0Hatem Belguith1Jeannette Ben Hamida2Unité de Protéomie Fonctionnelle and Biopréservation Alimentaire, Institut Supérieur des Sciences Biologiques Appliquées de Tunis, Université Tunis El Manar, Tunisie.Unité de Protéomie Fonctionnelle and Biopréservation Alimentaire, Institut Supérieur des Sciences Biologiques Appliquées de Tunis, Université Tunis El Manar, Tunisie.Unité de Protéomie Fonctionnelle and Biopréservation Alimentaire, Institut Supérieur des Sciences Biologiques Appliquées de Tunis, Université Tunis El Manar, Tunisie.Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a template for model building. This model was then assessed for stereochemical quality and side chain environment. Natural substrates: tributyrin, trioctanoin and triolen were docked into the model to investigate ligand-substrate interaction.https://doi.org/10.4137/EBO.S7122
collection DOAJ
language English
format Article
sources DOAJ
author Abdelmonaem Messaoudi
Hatem Belguith
Jeannette Ben Hamida
spellingShingle Abdelmonaem Messaoudi
Hatem Belguith
Jeannette Ben Hamida
Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method
Evolutionary Bioinformatics
author_facet Abdelmonaem Messaoudi
Hatem Belguith
Jeannette Ben Hamida
author_sort Abdelmonaem Messaoudi
title Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method
title_short Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method
title_full Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method
title_fullStr Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method
title_full_unstemmed Three-Dimensional Structure of Lipase Predicted by Homology Modeling Method
title_sort three-dimensional structure of lipase predicted by homology modeling method
publisher SAGE Publishing
series Evolutionary Bioinformatics
issn 1176-9343
publishDate 2011-01-01
description Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a template for model building. This model was then assessed for stereochemical quality and side chain environment. Natural substrates: tributyrin, trioctanoin and triolen were docked into the model to investigate ligand-substrate interaction.
url https://doi.org/10.4137/EBO.S7122
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AT hatembelguith threedimensionalstructureoflipasepredictedbyhomologymodelingmethod
AT jeannettebenhamida threedimensionalstructureoflipasepredictedbyhomologymodelingmethod
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