T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice

<p>Abstract</p> <p>Background</p> <p>Immunization against amyloid-β (Aβ), the peptide that accumulates in the form of senile plaques and in the cerebrovasculature in Alzheimer's disease (AD), causes a dramatic immune response that prevents plaque formation and clea...

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Bibliographic Details
Main Authors: de Calignon Alix, Spires-Jones Tara L, Mielke Matthew, Mora J Rodrigo, Meyer-Luehmann Melanie, von Andrian Ulrich H, Hyman Bradley T
Format: Article
Language:English
Published: BMC 2011-03-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/6/1/22