Stiffness analysis of 3D spheroids using microtweezers.
We describe a novel mechanical characterization method that has directly measured the stiffness of cancer spheroids for the first time to our knowledge. Stiffness is known to be a key parameter that characterizes cancerous and normal cells. Atomic force microscopy or optical tweezers have been typic...
Main Authors: | Devina Jaiswal, Norah Cowley, Zichao Bian, Guoan Zheng, Kevin P Claffey, Kazunori Hoshino |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5699838?pdf=render |
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