The role of Mediator and Little Elongation Complex in transcription termination
Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA...
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14849-1 |
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doaj-572c46f5a5fa44c2988bdd63d44df2412021-05-11T08:53:08ZengNature Publishing GroupNature Communications2041-17232020-02-0111112010.1038/s41467-020-14849-1The role of Mediator and Little Elongation Complex in transcription terminationHidehisa Takahashi0Amol Ranjan1Shiyuan Chen2Hidefumi Suzuki3Mio Shibata4Tomonori Hirose5Hiroko Hirose6Kazunori Sasaki7Ryota Abe8Kai Chen9Yanfeng He10Ying Zhang11Ichigaku Takigawa12Tadasuke Tsukiyama13Masashi Watanabe14Satoshi Fujii15Midori Iida16Junichi Yamamoto17Yuki Yamaguchi18Yutaka Suzuki19Masaki Matsumoto20Keiichi I. Nakayama21Michael P. Washburn22Anita Saraf23Laurence Florens24Shigeo Sato25Chieri Tomomori-Sato26Ronald C. Conaway27Joan W. Conaway28Shigetsugu Hatakeyama29Department of Molecular Biology, Yokohama City University Graduate School of Medical ScienceStowers Institute for Medical ResearchStowers Institute for Medical ResearchDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchGraduate School of Information Science and Technology, Hokkaido UniversityDepartment of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Bioscience and Bioinformatics, Kyushu Institute of TechnologyDepartment of Bioscience and Bioinformatics, Kyushu Institute of TechnologyDepartment of Nanoparticle Translational Research Tokyo Medical UniversityGraduate School of Bioscience and Biotechnology, Tokyo Institute of TechnologyLaboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of TokyoDepartment of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu UniversityDepartment of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu UniversityStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchDepartment of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityMediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies.https://doi.org/10.1038/s41467-020-14849-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hidehisa Takahashi Amol Ranjan Shiyuan Chen Hidefumi Suzuki Mio Shibata Tomonori Hirose Hiroko Hirose Kazunori Sasaki Ryota Abe Kai Chen Yanfeng He Ying Zhang Ichigaku Takigawa Tadasuke Tsukiyama Masashi Watanabe Satoshi Fujii Midori Iida Junichi Yamamoto Yuki Yamaguchi Yutaka Suzuki Masaki Matsumoto Keiichi I. Nakayama Michael P. Washburn Anita Saraf Laurence Florens Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Shigetsugu Hatakeyama |
| spellingShingle |
Hidehisa Takahashi Amol Ranjan Shiyuan Chen Hidefumi Suzuki Mio Shibata Tomonori Hirose Hiroko Hirose Kazunori Sasaki Ryota Abe Kai Chen Yanfeng He Ying Zhang Ichigaku Takigawa Tadasuke Tsukiyama Masashi Watanabe Satoshi Fujii Midori Iida Junichi Yamamoto Yuki Yamaguchi Yutaka Suzuki Masaki Matsumoto Keiichi I. Nakayama Michael P. Washburn Anita Saraf Laurence Florens Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Shigetsugu Hatakeyama The role of Mediator and Little Elongation Complex in transcription termination Nature Communications |
| author_facet |
Hidehisa Takahashi Amol Ranjan Shiyuan Chen Hidefumi Suzuki Mio Shibata Tomonori Hirose Hiroko Hirose Kazunori Sasaki Ryota Abe Kai Chen Yanfeng He Ying Zhang Ichigaku Takigawa Tadasuke Tsukiyama Masashi Watanabe Satoshi Fujii Midori Iida Junichi Yamamoto Yuki Yamaguchi Yutaka Suzuki Masaki Matsumoto Keiichi I. Nakayama Michael P. Washburn Anita Saraf Laurence Florens Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Shigetsugu Hatakeyama |
| author_sort |
Hidehisa Takahashi |
| title |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_short |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_full |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_fullStr |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_full_unstemmed |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_sort |
role of mediator and little elongation complex in transcription termination |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies. |
| url |
https://doi.org/10.1038/s41467-020-14849-1 |
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