Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition

Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition

Abstract Background Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to chemotherapy still have an adverse prognosis. Hence, development of new th...

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Bibliographic Details
Main Authors: Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler, Walter Berger
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Osteosarcoma
KP46
Anticancer gallium compound
Autophagy
Obatoclax
Online Access:http://link.springer.com/article/10.1186/s13046-017-0527-z

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