FORTIS: a live-cell assay to monitor AMPA receptors using pH-sensitive fluorescence tags

FORTIS: a live-cell assay to monitor AMPA receptors using pH-sensitive fluorescence tags

Abstract The real-time live fluorescent monitoring of surface AMPA receptors (AMPARs) could open new opportunities for drug discovery and phenotypic screening concerning neuropsychiatric disorders. We have developed FORTIS, a tool based on pH sensitivity capable of detecting subtle changes in surfac...

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Bibliographic Details
Main Authors: María Calleja-Felipe, Magdalena Natalia Wojtas, Marta Diaz-González, Dalila Ciceri, Raúl Escribano, Alberto Ouro, Miguel Morales, Shira Knafo
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01457-w

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