miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1

miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1

Glucagon-like peptide-1 (GLP-1) has been shown to potentiate glucose-stimulated insulin secretion binding GLP-1 receptor on pancreatic β cells. β-arrestin 1 (βARR1) is known to regulate the desensitization of GLP-1 receptor. Mounting evidence indicates that microRNAs (miRNAs, miRs) are fundamental i...

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Bibliographic Details
Main Authors: Alessandro Matarese, Jessica Gambardella, Angela Lombardi, Xujun Wang, Gaetano Santulli
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
β-arrestin 1
cAMP
diabetes
epigenetics
glucose-stimulated insulin secretion (GSIS)
miRNA-7
Online Access:https://www.mdpi.com/2073-4409/9/7/1621

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