The association of lipoprotein(a) and apolipoprotein(a) phenotypes with peripheral artery disease

• Main Authors: N A Tmoyan, M V Ezhov, O I Afanasieva, E A Klesareva, O A Razova, V V Kukharchuk, S N Pokrovsky
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2018-09-01
• Series: Терапевтический архив
• Subjects: lipoprotein(a); apolipoprotein(a) phenotypes; atherosclerosis; peripheral artery disease; atherosclerosis of lower limbs arteries
• Online Access: https://ter-arkhiv.ru/0040-3660/article/viewFile/32986/pdf

Aim. Lipoprotein(a) [Lp(a)] is an independent risk factor of coronary heart disease (CHD) and myocardial infarction. Data about the role of Lp(a) in the development of peripheral artery disease (PAD) is controversial and uncertain. The aim of the study was to evaluate the association between Lp(a), apolipoprotein(a) [apo(a)] phenotypes and PAD. Materials and methods. The study included 998 patients (707 male and 291 female, average age 60±12). The patients were divided into 4 groups depending on the presence or absence PAD and CHD: group I (n=188, PAD+CHD+), group II (n=78, PAD+CHD-), group III (n=407, PAD-CHD+), group IV (n=325, PAD-CHD-). Results. The level of Lp(a) was significantly higher in groups I, II, III in comparison with patients of control group (group IV): 34 [15; 80], 30 [10; 49], 22 [8; 60] mg/dl vs. 15 [6; 35] mg/dl respectively, p