Enhanced oxidative stress is responsible for TRPV4-induced neurotoxicity

Enhanced oxidative stress is responsible for TRPV4-induced neurotoxicity

Transient receptor potential vanilloid 4 (TRPV4) has been reported to be responsible for neuronal injury in pathological conditions. Excessive oxidative stress can lead to neuronal damage, and activation of TRPV4 increases the production of reactive oxygen species and nitric oxide (NO) in many types...

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Bibliographic Details
Main Authors: Zhiwen Hong, Yujing Tian, Yibiao Yuan, Mengwen Qi, Yingchun Li, Yimei Du, Lei Chen, Ling Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Oxidative Stress
Neurotoxicity
NOS
Ca2+
TRPV4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00232/full

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