Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in co...

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Bibliographic Details
Main Authors: Wojciech Król, Katarzyna Jernas, Zenon P. Czuba, Ewelina Szliszka
Format: Article
Language:English
Published: MDPI AG 2008-01-01
Series:International Journal of Molecular Sciences
Subjects:
Dietary flavonoids
TRAIL
HeLa
chemoprevention
antitumoral activity.
Online Access:http://www.mdpi.com/1422-0067/9/1/56/
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spelling doaj-570908bbad7b405b8770a93b5fd9982a2020-11-25T00:13:46ZengMDPI AGInternational Journal of Molecular Sciences1422-00672008-01-01915664Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)Wojciech KrólKatarzyna JernasZenon P. CzubaEwelina SzliszkaTRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.http://www.mdpi.com/1422-0067/9/1/56/Dietary flavonoidsTRAILHeLachemopreventionantitumoral activity.
collection DOAJ
language English
format Article
sources DOAJ
author Wojciech Król
Katarzyna Jernas
Zenon P. Czuba
Ewelina Szliszka
spellingShingle Wojciech Król
Katarzyna Jernas
Zenon P. Czuba
Ewelina Szliszka
Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
International Journal of Molecular Sciences
Dietary flavonoids
TRAIL
HeLa
chemoprevention
antitumoral activity.
author_facet Wojciech Król
Katarzyna Jernas
Zenon P. Czuba
Ewelina Szliszka
author_sort Wojciech Król
title Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_short Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_full Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_fullStr Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_full_unstemmed Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_sort dietary flavonoids sensitize hela cells to tumor necrosis factor-related apoptosis-inducing ligand (trail)
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2008-01-01
description TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.
topic Dietary flavonoids
TRAIL
HeLa
chemoprevention
antitumoral activity.
url http://www.mdpi.com/1422-0067/9/1/56/
work_keys_str_mv AT wojciechkraƒa3l dietaryflavonoidssensitizehelacellstotumornecrosisfactorrelatedapoptosisinducingligandtrail
AT katarzynajernas dietaryflavonoidssensitizehelacellstotumornecrosisfactorrelatedapoptosisinducingligandtrail
AT zenonpczuba dietaryflavonoidssensitizehelacellstotumornecrosisfactorrelatedapoptosisinducingligandtrail
AT ewelinaszliszka dietaryflavonoidssensitizehelacellstotumornecrosisfactorrelatedapoptosisinducingligandtrail
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